surface modification of mesoporous nanosilica with [3-(2-aminoethylamino) propyl] trimethoxysilane and its application in drug delivery

mesoporous silica nanoparticles with unique structure (sba-15) were synthesized and modified by [3-(2-aminoethylamino) propyl] trimethoxysilane (aeaptms). the synthesized nanoparticles were characterized by tga, n­2­ adsorption, sem, ftir, chn elemental analysis. the total weight loss for the modified sba-15 is 15.2% and thermal analysis revealed that 1.5 mmol aeaptms/1g sba-15 had been grafted. the modified particles were used as a drug delivery system. ibuprofen as common nonsteroidal anti-inflammatory drugs was used to evaluate the controlled drug release properties of modified sba-15.the results show that the modification of sba-15 with organic groups such as [3-(2-aminoethylamino) propyl] trimethoxysilane and (3-aminopropyl) triethoxysilane (aptes) improve the organophilicity of the sba-15 and the drug loading efficiency. the results of drug delivery experiments reveal that the surface modification of sba-15 with amino groups significantly decreases the drug delivery rate. the data obtained from the in vitro release studies was used to evaluate the kinetic mechanism of release; the initial 60% release of drug at ph 7.4 fits with the korsmeyer – peppas model, when diffusion is the main drug release mechanism.